Molecule
Avacincaptad pegol is a complement inhibitor indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). It is available as injection for intravitreal use. MedsAcross supplies Avacincaptad pegol for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
From the regulator-approved product information. Each section names its source.
IZERVAY ® is indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). IZERVAY is a complement inhibitor indicated for the treatment of geographic atrophy (GA) secondary to age-related macular degeneration (AMD).
Source: US FDA prescribing information
Avacincaptad pegol is an RNA aptamer, a PEGylated oligonucleotide that binds to and inhibits complement protein C5. By inhibiting C5, avacincaptad pegol may prevent its cleavage to C5a and C5b thus decreasing membrane attack complex (MAC) formation.
Source: US FDA prescribing information
The recommended dosage for IZERVAY is 2 mg (0.1 mL of 20 mg/mL solution) administered by intravitreal injection to each affected eye once monthly (approximately 28 ± 7 days).
Source: US FDA prescribing information
• Ocular or periocular infections. • Active intraocular inflammation. Ocular or Periocular Infections IZERVAY is contraindicated in patients with ocular or periocular infections.
Source: US FDA prescribing information
• Endophthalmitis and Retinal Detachments. • Neovascular AMD. • Increase in Intraocular Pressure (IOP). Endophthalmitis and Retinal Detachments Intravitreal injections may be associated with endophthalmitis and retinal detachments. Proper aseptic injection techniques must always be used when administering IZERVAY in order to minimize the risk of endophthalmitis. Patients should be instructed to report any symptoms suggestive of endophthalmitis or retinal detachment without delay, to permit prompt and appropriate management. Neovascular AMD In the GATHER1 and GATHER2 clinical trials, use of IZERVAY was associated with increased rates of neovascular (wet) AMD or choroidal neovascularization (7% when administered monthly and 4% in the sham group) by Month 12.
Source: US FDA prescribing information
The following potentially serious adverse reactions are described elsewhere in the labeling: • Ocular and periocular infections • Active intraocular inflammation • Endophthalmitis and retinal detachments • Neovascular AMD • Increase in intraocular pressure The most common adverse reactions (incidence ≥ 5%) were conjunctival hemorrhage, increased IOP, blurred vision, neovascular age-related macular degeneration, punctate keratitis, and eye pain.
Source: US FDA prescribing information
Store IZERVAY in the refrigerator between 2°C to 8°C (36°F to 46°F). Do not freeze. Prior to use, the unopened glass vial of IZERVAY may be kept at room temperature, 20°C to 25°C (68°F to 77°F), for up to 24 hours. Do not shake. Keep the vial in the original carton to protect from light.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
1 presentations of Avacincaptad pegol, sorted by availability.
| Medicine | Manufacturer | Register | Availability |
|---|---|---|---|
| Izervay 7 mg/0.35 mL injectionIntravitreal Cold chain | Astellas Pharma | US FDA | Available on request |
1 brand names across 1 markets.
United States
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
Yes, on request. MedsAcross lists 1 presentations of Avacincaptad pegol and sources them for licensed hospitals, importers and physicians against valid import documents.
The catalogue lists 1 brand names for Avacincaptad pegol, including Izervay.
Yes. The US FDA first approved Avacincaptad pegol on 4 August 2023, according to Drugs@FDA.
At least one listed presentation of Avacincaptad pegol must be kept cold, so it is shipped in temperature-controlled packaging. Check the storage line on each presentation.
Avacincaptad pegol is classified under ATC code S01XA32 (Avacincaptad pegol).
Tell us the strength, quantity and destination country. Our team replies with availability, lead time and the import documents needed.