Uses
Plegisol (Cardioplegic Solution) when suitably buffered in combination with ischemia and hypothermia is used to induce cardiac arrest during open heart surgery.
Source: US FDA prescribing information
Fixed-dose combination
Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride
Also known as calcium chloride, magnesium chloride, potassium chloride, sodium chloride
Available on request
- Presentations
- 3
- Brands
- 3
- Manufacturers
- 3
- Available from stock
- 0
Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride is a fixed-dose combination of an osmotic laxative, a blood coagulation factor and a calculi dissolution agent. MedsAcross supplies Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
Key facts
- Pharmacological class
- Osmotic Laxative, Blood Coagulation Factor, Calculi Dissolution Agent, Cations, Potassium Salt, Phosphate Binder, Osmotic Activity, Magnesium Ion Exchange Activity, Phosphate Chelating Activity, Increased Large Intestinal Motility, Inhibition Large Intestine Fluid/Electrolyte Absorption, Increased Coagulation Factor Activity
- US FDA first approval
- 26 February 1982
- EU status
- Not recorded
- Orphan designation
- Not recorded
- WHO essential medicine
- Not recorded
- India (CDSCO)
- Not yet confirmed against CDSCO approval lists
- Routes
- Intra-arterial
- Dosage forms
- Injection
- Fixed-dose combination of
- Calcium chloride, Magnesium chloride, Potassium chloride, Sodium chloride
Clinical information
From the regulator-approved product information. Each section names its source.
Dosing overview
The following information is suggested as a guide and is subject to variation according to the preference and experience of the surgeon. It is required that 10 mL (840 mg) of 8.4% Sodium Bicarbonate Injection, USP (10 mEq each of sodium and bicarbonate) be added aseptically and thoroughly mixed with each 1000 mL of cardioplegic solution to adjust pH. Use 10 mL of Hospira List 4900, 8.4% Sodium Bicarbonate Injection, USP, to achieve the approximate pH of 7.8 when measured at room temperature. Use of any other Sodium Bicarbonate Injection may not achieve this pH due to the varying pH's of Sodium Bicarbonate Injections. Due to its inherent instability with other components, sodium bicarbonate must be added just prior to administration. After this addition, the solution must be used within 24 hours. The solution should be cooled to 4°C prior to use.
Source: US FDA prescribing information
Contraindications
Plegisol must not be administered without the addition of 8.4% Sodium Bicarbonate Injection, USP, Hospira List 4900. NOT FOR INTRAVENOUS INJECTION. This solution is only for instillation into cardiac vasculature after buffering with sodium bicarbonate.
Source: US FDA prescribing information
Warnings and precautions
This solution should be used only by those trained to perform open heart surgery. This solution is intended only for use during cardiopulmonary bypass when the coronary circulation is isolated from the systemic circulation. Do not instill the solution into the coronary vasculature unless sodium bicarbonate has been added. If large volumes of cardioplegic solution are infused and allowed to return to the heart lung machine without any venting from the right heart, then plasma magnesium and potassium levels may rise. Development of severe hypotension and metabolic acidosis while on bypass has been reported when large volumes (8 to 10 liters) of solution are instilled and allowed to enter the pump and then the systemic circulation. Right heart venting is therefore recommended.
Source: US FDA prescribing information
Side effects
Intraoperative and perioperative potential hazards of open heart surgery include myocardial infarction, electrocardiographic abnormalities, and arrhythmias, including ventricular fibrillation. Spontaneous recovery after cardioplegic cardiac arrest may be delayed or absent when circulation is restored. Defibrillation by electric shock may be required to restore normal cardiac function.
Source: US FDA prescribing information
Interactions
Additives may be incompatible. Consult with pharmacist, if available. When introducing additives, use aseptic technique, mix thoroughly and do not store.
Source: US FDA prescribing information
Storage
Store at 20°C to 25°C (68°F to 77°F). Protect from freezing.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
All presentations
3 presentations of Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride, sorted by availability.
| Medicine | Active ingredient | Manufacturer | Register | Availability |
|---|---|---|---|---|
| Cardioplegic 176 mg/3253 mg/1193 mg/6430 mg per 1000 mL injectionIntra-arterial | Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride | Baxter Healthcare | US FDA | Available on request |
| Cardioplegic Solution 176 mg/3253 mg/1193 mg/6430 mg per 1000 mL injectionIntra-arterial | Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride | Fresenius Kabi | US FDA | Available on request |
| Plegisol 176 mg/3253 mg/1193 mg/6430 mg per 1000 mL injectionIntra-arterial | Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride | Hospira | US FDA | Available on request |
Brands by market
3 brand names across 1 markets.
United States
Manufacturers
Regulatory status
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
| Register | Status | Source |
|---|---|---|
| US FDA | First approved 26 February 1982 | Drugs@FDA |
| EU (EMA) | Not recorded | — |
| India (CDSCO) | Not yet confirmed against CDSCO approval lists | — |
| United States | Registered | US FDA (NDC directory, openFDA)Checked 12 November 2026 |
Questions and answers
Is Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride available for export from India?
Yes, on request. MedsAcross lists 3 presentations of Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride and sources them for licensed hospitals, importers and physicians against valid import documents.
What brand names does Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride have?
The catalogue lists 3 brand names for Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride, including Cardioplegic, Cardioplegic Solution, Plegisol.
Is Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride approved by the US FDA?
Yes. The US FDA first approved Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride on 26 February 1982, according to Drugs@FDA.
Does Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride need cold chain shipping?
No listed presentation of Calcium chloride, Magnesium chloride, Potassium chloride and Sodium chloride is recorded as needing a cold chain. Storage conditions are shown on each presentation page.
References
- Plegisol prescribing information (Hospira). U.S. National Library of Medicine, DailyMed. Retrieved 27 May 2026
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