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Molecule

Ceftriaxone

Also known as ceftriaxone sodium
Available on requestCold chainAntibiotics
Presentations
11
Brands
0
Manufacturers
0
Available from stock
0

Ceftriaxone is a cephalosporin antibacterial indicated for the treatment of infections when caused by susceptible bacteria, among other approved uses. It is available as powder for injection and injection for intravenous and intramuscular use. MedsAcross supplies Ceftriaxone for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.

Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review

Key facts

Pharmacological class
Cephalosporin Antibacterial
ATC classification
J01DD04 Ceftriaxone · Cephalosporin antibiotic
US FDA first approval
21 December 1984
EU status
Not recorded
Orphan designation
Not recorded
WHO essential medicine
Not recorded
India (CDSCO)
Not yet confirmed against CDSCO approval lists
Routes
Intravenous, Intramuscular
Dosage forms
Powder for injection, Injection
Identifiers
UNII 75J73V1629RxCUI 2193CAS 73384-59-5DrugBank DB01212Q421713

Clinical information

From the regulator-approved product information. Each section names its source.

Uses

Ceftriaxone for Injection and Dextrose Injection is indicated for the treatment of the following infections when caused by susceptible bacteria. Ceftriaxone for Injection and Dextrose Injection is a cephalosporin antibacterial indicated for the treatment of the following infections caused by susceptible isolates of the designated bacteria: Lower Respiratory Tract Infections, Skin and Skin Structure Infections, Complicated and Uncomplicated Urinary Tract Infections, Pelvic Inflammatory Disease, Bacterial Septicemia, Bone and Joint Infections, Intra-abdominal Infections, Meningitis, and Surgical Prophylaxis.

Source: US FDA prescribing information

Dosing overview

For intravenous use only over approximately 30 minutes. Use this formulation of ceftriaxone only in patients who require the entire 1 or 2 gram dose and not any fraction thereof. Recommended Dosing Schedule for Ceftriaxone for Injection and Dextrose Injection Site and Type of Infection Dose Frequency Total Daily Dose Usual Adult Dose 1 g to 2 g once a day or in equally divided doses every 12 hours should not exceed 4 g Patients with hepatic impairment and significant renal impairment should not receive more than 2 grams per day of ceftriaxone.

Source: US FDA prescribing information

Contraindications

Anaphylaxis to ceftriaxone or other cephalosporin class antibacterials, penicillins, or other beta-lactam antibacterials Anaphylaxis to Ceftriaxone or the Cephalosporin Class of Antibacterials, Penicillins, or Other Beta-lactam Antibacterials Ceftriaxone for Injection and Dextrose Injection is contraindicated in patients who have a history of anaphylaxis to ceftriaxone or the cephalosporin class of antibacterials, penicillins, or other beta-lactam antibacterials.

Source: US FDA prescribing information

Warnings and precautions

Hypersensitivity reactions: Include anaphylaxis and serious skin reactions. Cross-hypersensitivity may occur in up to 10% of patients with a history of penicillin allergy. If an allergic reaction occurs, discontinue the drug. Interaction with Calcium-containing Products: Precipitation can occur. Do not administer simultaneously with calcium-containing IV solutions. Clostridioides difficile -associated diarrhea: May range from mild diarrhea to fatal colitis. Evaluate if diarrhea occurs. Neurological Adverse Reactions: Serious neurological adverse reactions have been reported. If neurological adverse reactions occur, discontinue Ceftriaxone for Injection and Dextrose Injection therapy and institute appropriate supportive measures. Make appropriate dosage adjustments in patients with severe renal impairment.

Source: US FDA prescribing information

Side effects

The following serious adverse reactions to ceftriaxone are described below and elsewhere in the labeling: Hypersensitivity reactions Ceftriaxone-calcium precipitates Neurological Adverse Reactions Clostridioides difficile -associated diarrhea Hemolytic anemia The most common adverse reactions occurring in greater than 2% of patients receiving ceftriaxone include diarrhea, eosinophilia, thrombocytosis, leukopenia, and elevations of SGOT and SGPT.

Source: US FDA prescribing information

Interactions

Vancomycin, amsacrine, aminoglycosides, and fluconazole are physically incompatible. Calcium-containing products: precipitation can occur.

Source: US FDA prescribing information

Storage

Store the unactivated unit at 20-25°C (68-77°F). Excursions permitted to 15-30°C (59-86°F). Do not freeze. Precautions As with other cephalosporins, reconstituted Ceftriaxone for Injection and Dextrose Injection tends to darken depending on storage conditions, within the stated recommendations.

Source: US FDA prescribing information

For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.

All presentations

11 presentations of Ceftriaxone, sorted by availability.

MedicineManufacturerRegisterAvailability
Ceftriaxone 1 g powder for injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request
Ceftriaxone 500 mg powder for injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request
Ceftriaxone 2 g powder for injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request
Ceftriaxone 250 mg powder for injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request
Ceftriaxone 10 g powder for injectionIntravenousGeneric name—US FDAAvailable on request
Ceftriaxone 10 g/100 mL powder for injectionIntravenousGeneric name—US FDAAvailable on request
Ceftriaxone 1 g/50 mL injectionIntravenous Cold chainGeneric name—US FDAAvailable on request
Ceftriaxone 2 g/50 mL injectionIntravenousGeneric name—US FDAAvailable on request
Ceftriaxone 1 g powder for injectionIntravenousGeneric name—US FDAAvailable on request
Ceftriaxone 100 g powder for injectionIntravenousGeneric name—US FDAAvailable on request
Ceftriaxone 2 g powder for injectionIntravenousGeneric name—US FDAAvailable on request

Regulatory status

Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.

RegisterStatusSource
US FDAFirst approved 21 December 1984Drugs@FDA
EU (EMA)Not recorded—
India (CDSCO)Not yet confirmed against CDSCO approval lists—
United StatesRegisteredUS FDA (NDC directory, openFDA)Checked 12 November 2026

Conditions

Conditions linked to Ceftriaxone in public data. This is not a list of approved uses, see the clinical information.

Bacterial meningitis Bacterial pneumonia Cellulitis Chancroid Enteritis Epididymitis Erysipelas Erysipelothrix rhusiopathiae infectious disease Escherichia coli infectious disease Far East scarlet-like fever Female reproductive system disease Gonorrhea Gram-negative bacterial infection Infectious bone disease Infective endocarditis Leptospirosis Louse-borne relapsing fever Lyme disease Meningitis Meningococcal disease Otitis media Paratyphoid fever Pelvic inflammatory diseases Peritonitis Pneumococcal infection Pneumonia Proctitis Sepsis Shigellosis Staphylococcal infection Syphilis Tabes dorsalis Trench fever Typhoid fever Upper respiratory tract infection Urinary tract infection Yersiniosis

Questions and answers

Is Ceftriaxone available for export from India?

Yes, on request. MedsAcross lists 11 presentations of Ceftriaxone and sources them for licensed hospitals, importers and physicians against valid import documents.

Is Ceftriaxone approved by the US FDA?

Yes. The US FDA first approved Ceftriaxone on 21 December 1984, according to Drugs@FDA.

Does Ceftriaxone need cold chain shipping?

At least one listed presentation of Ceftriaxone must be kept cold, so it is shipped in temperature-controlled packaging. Check the storage line on each presentation.

Which ATC class is Ceftriaxone in?

Ceftriaxone is classified under ATC code J01DD04 (Ceftriaxone).

References

  1. CEFTRIAXONE AND DEXTROSE prescribing information (B. Braun Medical). U.S. National Library of Medicine, DailyMed. Retrieved 13 January 2022

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