Fixed-dose combination
Clindamycin and Tretinoin is a fixed-dose combination of a lincosamide antibacterial and a retinoid indicated for the topical treatment of acne vulgaris in patients 12 years or older. MedsAcross supplies Clindamycin and Tretinoin for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
From the regulator-approved product information. Each section names its source.
ZIANA Gel is indicated for the topical treatment of acne vulgaris in patients 12 years or older. ZIANA ® Gel is a lincosamide antibiotic and retinoid combination product indicated for the topical treatment of acne vulgaris in patients 12 years or older.
Source: US FDA prescribing information
Clindamycin Tretinoin Although the exact mode of action of tretinoin is unknown, current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.
Source: US FDA prescribing information
At bedtime, squeeze a pea-sized amount of medication onto one fingertip, dot onto the chin, cheeks, nose, and forehead, then gently rub over the entire face. ZIANA Gel should be kept away from the eyes, the mouth, angles of the nose, and mucous membranes. ZIANA Gel is not for oral, ophthalmic, or intravaginal use. • Apply a pea-sized amount to the entire face once daily at bedtime. Do not apply to eyes, mouth, angles of the nose, or mucous membranes. • ZIANA Gel is not for oral, ophthalmic, or intravaginal use.
Source: US FDA prescribing information
ZIANA Gel is contraindicated in patients with regional enteritis, ulcerative colitis, or history of antibiotic-associated colitis.
Source: US FDA prescribing information
• Colitis: Clindamycin can cause severe colitis, which may result in death. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of clindamycin. ZIANA Gel should be discontinued if significant diarrhea occurs. • Ultraviolet Light and Environmental Exposures: Avoid exposure to sunlight and sunlamps. Wear sunscreen daily.
Source: US FDA prescribing information
Observed local adverse reactions in patients treated with ZIANA Gel were skin erythema, scaling, itching, burning, and stinging. Other most commonly reported adverse events (≥1% in patients treated with ZIANA Gel) were nasopharyngitis, pharyngolaryngeal pain, dry skin, cough, and sinusitis.
Source: US FDA prescribing information
• Concomitant use of topical medications with a strong drying effect can increase skin irritation. Use with caution. • ZIANA Gel should not be used in combination with erythromycin-containing products because of its clindamycin component.
Source: US FDA prescribing information
Store at 25°C (77°F), excursions permitted to 15° to 30°C (59° to 86°F). • Protect from light. • Protect from freezing. • Keep out of the reach of children. • Keep away from heat. • Keep tube tightly closed.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
3 presentations of Clindamycin and Tretinoin, sorted by availability.
| Medicine | Active ingredient | Manufacturer | Register | Availability |
|---|---|---|---|---|
| Clindamycin and Tretinoin 10 mg/0.25 mg per g gelTopicalGeneric name | Clindamycin and Tretinoin | — | US FDA | Available on request |
| Clindamycin and Tretinoin 12 mg/0.25 mg per g gelTopicalGeneric name | Clindamycin and Tretinoin | — | US FDA | Available on request |
| Ziana 12 mg/0.25 mg per g gelTopical | Clindamycin and Tretinoin | Bausch Health | US FDA | Available on request |
1 brand names across 1 markets.
United States
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
| Register | Status | Source |
|---|---|---|
| US FDA | First approved 7 November 2006 | Drugs@FDA |
| EU (EMA) | Not recorded | — |
| India (CDSCO) | Not yet confirmed against CDSCO approval lists | — |
| United States | Registered | US FDA (NDC directory, openFDA)Checked 12 November 2026 |
Yes, on request. MedsAcross lists 3 presentations of Clindamycin and Tretinoin and sources them for licensed hospitals, importers and physicians against valid import documents.
The catalogue lists 1 brand names for Clindamycin and Tretinoin, including Ziana.
Yes. The US FDA first approved Clindamycin and Tretinoin on 7 November 2006, according to Drugs@FDA.
No listed presentation of Clindamycin and Tretinoin is recorded as needing a cold chain. Storage conditions are shown on each presentation page.
Tell us the strength, quantity and destination country. Our team replies with availability, lead time and the import documents needed.