Molecule
Ephedrine is a norepinephrine releasing agent indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia. It is available as injection for intravenous use. MedsAcross supplies Ephedrine for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
From the regulator-approved product information. Each section names its source.
AKOVAZ (ephedrine sulfate injection) is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia. AKOVAZ injection is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent that is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia.
Source: US FDA prescribing information
Ephedrine sulfate is a sympathomimetic amine that directly acts as an agonist at α- and β-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. Pressor effects by direct alpha- and beta-adrenergic receptor activation are mediated by increases in arterial pressures, cardiac output, and peripheral resistance. Indirect adrenergic stimulation is caused by norepinephrine release from sympathetic nerves.
Source: US FDA prescribing information
• Should be administered by trained healthcare providers. • AKOVAZ injection, 50 mg/mL, must be diluted before administration as an intravenous bolus dose. • AKOVAZ injection, 5 mg/mL in a pre-filled syringe, is a premixed formulation. Do not dilute prior to use. • Bolus intravenous injection: 5 mg to 10 mg as needed, not to exceed 50 mg.
Source: US FDA prescribing information
None None
Source: US FDA prescribing information
• Pressor Effects with Concomitant Use with Oxytocic Drugs: Pressor effect of sympathomimetic pressor amines is potentiated. • Tachyphylaxis and Tolerance: Repeated administration of ephedrine may cause tachyphylaxis
Source: US FDA prescribing information
The following adverse reactions associated with the use of ephedrine sulfate were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure. Gastrointestinal disorders: Nausea, vomiting Cardiac disorders: Tachycardia, palpitations (thumping heart), reactive hypertension, bradycardia, ventricular ectopics, R-R variability Nervous system disorders: Dizziness Psychiatric disorders: Restlessness Most common adverse reactions during treatment: nausea, vomiting, and tachycardia.
Source: US FDA prescribing information
Interactions that Augment the Pressor Effect Oxytocin and oxytocic drugs Clinical Impact: Serious postpartum hypertension has been described in patients who received both a vasopressor (i.e., methoxamine, phenylephrine, ephedrine) and an oxytocic (i.e., methylergonovine, ergonovine). Some of these patients experienced a stroke. Intervention: Carefully monitor the blood pressure of individuals who have received both ephedrine and an oxytocic. Clonidine, propofol, monoamine oxidase inhibitors (MAOIs), atropine Clinical Impact: These drugs augment the pressor effect of ephedrine. Intervention: Carefully monitor the blood pressure of individuals who have received both ephedrine and any of these drugs. Interactions that Antagonize the Pressor Effect Clinical Impact: These drugs antagonize the pressor effect of ephedrine.
Source: US FDA prescribing information
Store AKOVAZ (ephedrine sulfate injection), at 25°C (77°F), excursions permitted to 15°C to 30°C (59°F to 86°F). Store in carton until time of use.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
9 presentations of Ephedrine, sorted by availability.
| Medicine | Manufacturer | Register | Availability |
|---|---|---|---|
| Ephedrine 50 mg/1 mL injectionIntravenousGeneric name | — | US FDA | Available on request |
| Ephedrine 50 mg/10 mL injectionIntravenousGeneric name | — | US FDA | Available on request |
| Ephedrine 25 mg/5 mL injectionIntravenousGeneric name | — | US FDA | Available on request |
| Akovaz 25 mg/5 mL injectionIntravenous | Exela Pharma Sciences | US FDA | Available on request |
| Akovaz 50 mg/1 mL injectionIntravenous | Exela Pharma Sciences | US FDA | Available on request |
| Emerphed 50 mg/10 mL injectionIntravenous | Nexus Pharamaceuticals | US FDA | Available on request |
| Emerphed PFS 25 mg/5 mL injectionIntravenous | Nexus Pharmaceuticals | US FDA | Available on request |
| Emerphed PFS 50 mg/10 mL injectionIntravenous | Nexus Pharmaceuticals | US FDA | Available on request |
| Ephedrine 50 mg/mL injectionIntravenousGeneric name | — | US FDA | Available on request |
3 brand names across 1 markets.
United States
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
| Register | Status | Source |
|---|---|---|
| US FDA | First approved 29 April 2016 | Drugs@FDA |
| EU (EMA) | Not recorded | — |
| India (CDSCO) | Not yet confirmed against CDSCO approval lists | — |
| United States | Registered | US FDA (NDC directory, openFDA)Checked 12 November 2026 |
Conditions linked to Ephedrine in public data. This is not a list of approved uses, see the clinical information.
Yes, on request. MedsAcross lists 9 presentations of Ephedrine and sources them for licensed hospitals, importers and physicians against valid import documents.
The catalogue lists 3 brand names for Ephedrine, including Akovaz, Emerphed, Emerphed PFS.
Yes. The US FDA first approved Ephedrine on 29 April 2016, according to Drugs@FDA.
No listed presentation of Ephedrine is recorded as needing a cold chain. Storage conditions are shown on each presentation page.
Ephedrine is classified under ATC code C01CA26 (Ephedrine).
Tell us the strength, quantity and destination country. Our team replies with availability, lead time and the import documents needed.