Molecule
Histamine is a prescription medicine indicated as an adjunct in allergy skin test for diagnosis, as a positive control to test wheal-flare response of skin for evaluation of skin test response to allergenic extracts. MedsAcross supplies Histamine for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
From the regulator-approved product information. Each section names its source.
Positive Skin Test Control - Histamine is indicated as an adjunct in allergy skin test for diagnosis, as a positive control to test wheal-flare response of skin for evaluation of skin test response to allergenic extracts.
Source: US FDA prescribing information
. General Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Prior to testing, clean the skin area with ether or alcohol and allow to dry. The back or the volar surface of the arms are the most satisfactory sites for testing. Skin of the posterior thighs or abdomen may be used if necessary. Avoid very hairy areas where possible, since the reactions will be smaller and more difficult to interpret there. The most satisfactory areas of the back are from the posterior axillary fold to 2.5 cm from the spinal column, and from the top of the scapula to the lower rib margins. The best areas of the arms are the volar surfaces from the axilla to 2.5 or 5 cm above the wrist, skipping the anti-cubital space.
Source: US FDA prescribing information
Positive Skin Test Control - Histamine is contraindicated in patients with a history of hypersensitivity to histamine products, and in patients with hypotension, severe hypertension, vasomotor instability, severe cardiac, pulmonary or renal disease.
Source: US FDA prescribing information
POSITIVE SKIN TEST CONTROL - HISTAMINE For Percutaneous (Scratch, Prick or Puncture) Administration Histamine Base: 6mg/mL (Histamine Dihydrochloride: 10mg/mL) This product is to be used by a physician or under the supervision of a physician. Attacks of severe asthma or other serious allergic conditions may be precipitated by the administration of Histamine Dihydrochloride in patients with bronchial disease. Caution is advised in using histamine in such patients and in those with a history of bronchial asthma. Histamine Dihydrochloride has not been approved for unlabeled use as gastric acid stimulus or for detecting bronchial hyperactivity.
Source: US FDA prescribing information
Large doses of histamine may precipitate systemic reactions. These reactions may include flushing, dizziness, headache, bronchial constriction, urticaria, asthma, marked hypotension or hypertension, abdominal cramps, vomiting, metallic taste, local or generalized allergic manifestations. An antihistamine preparation may be given orally, I.M. or I.V. to prevent or ameliorate systemic reactions to the drug. If a systemic or anaphylactic reaction does occur, apply a tourniquet above the site of injection and inject 1:1000 epinephrine-hydrochloride intramuscularly or subcutaneously into the opposite arm. Loosen the tourniquet at least every 10 minutes. Do not obstruct arterial blood flow with the tourniquet. Epinephrine Dosage: ADULT: 0.3 to 0.5 mL should be injected. Repeat in 5 to 10 minutes if necessary.
Source: US FDA prescribing information
. Drug Interactions: Certain medications may lessen the skin test wheal and erythema responses elicited by histamine for varying time periods. Conventional antihistamines should be discontinued at least 5 days before skin testing. Long acting antihistamines should be discontinued for at least 3 weeks prior to skin testing. 7 Topical steroids should be discontinued at the skin test site for at least 2-3 weeks before skin testing. 7,8 Tricyclic antidepressants such as Doxepin should be withheld for at least 7 days before skin testing. 9 The physician must determine whether the risk of severe depression occurring in patients who discontinue their medication outweighs the benefits that could be obtained from skin testing. Topical local anesthetics may suppress the flare responses and should be avoided in skin test sites. 10
Source: US FDA prescribing information
Store at 2°- 8°C. Protect from light when not in use.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
3 presentations of Histamine, sorted by availability.
| Medicine | Manufacturer | Register | Availability |
|---|---|---|---|
| histamine positive skin test control 1.375 mg/5 mL injectionIntradermal Cold chain | ALK-Abello | US FDA | Available on request |
| Histamine Positive Skin Test Control 2.75 mg/mL topical solutionPercutaneous Cold chain | ALK-Abello | US FDA | Available on request |
| Positive Skin Test Control - Histamine 30 mg/5 mL injectionPercutaneous Cold chain | Jubilant HollisterStierIndia | US FDA | Available on request |
2 brand names across 1 markets.
Indian manufacturers are highlighted.
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
Yes, on request. MedsAcross lists 3 presentations of Histamine and sources them for licensed hospitals, importers and physicians against valid import documents. Indian manufacturers include Jubilant HollisterStier.
The catalogue lists 3 brand names for Histamine, including Histamine Positive Skin Test Control, histamine positive skin test control, Positive Skin Test Control - Histamine.
Yes. The US FDA first approved Histamine on 25 April 1939, according to Drugs@FDA.
Yes. Histamine has a central EU marketing authorisation (status: authorised), according to European Medicines Agency data.
At least one listed presentation of Histamine must be kept cold, so it is shipped in temperature-controlled packaging. Check the storage line on each presentation.
Histamine is classified under ATC code L03AX14 (Histamine).
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