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Molecule

Isoproterenol

Also known as isoproterenol hydrochloride
Available on requestCardiologyRespiratory
Presentations
6
Brands
0
Manufacturers
0
Available from stock
0

Isoproterenol is a beta-adrenergic agonist indicated to improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output, among other approved uses. It is available as injection for intravenous, intramuscular and intracardiac use. MedsAcross supplies Isoproterenol for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.

Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review

Key facts

Pharmacological class
Beta-Adrenergic Agonist, Adrenergic beta-Agonists
ATC classification
C01CA02 Isoproterenol · ButyroxanR03AB02 Isoproterenol · Asthma and COPD medicines, subgroup R03A, subgroup R03ABR03CB01 Isoproterenol · Asthma and COPD medicines, subgroup R03C, subgroup R03CB
US FDA first approval
19 February 1948
EU status
Not recorded
Orphan designation
Not recorded
WHO essential medicine
Not recorded
India (CDSCO)
Not yet confirmed against CDSCO approval lists
Routes
Intravenous, Intramuscular, Intracardiac, Subcutaneous
Dosage forms
Injection
Identifiers
UNII L628TT009WRxCUI 6054CAS 7683-59-2DrugBank DB01064Q415550

Clinical information

From the regulator-approved product information. Each section names its source.

Uses

Isoproterenol hydrochloride injection is indicated: • To improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output • For bronchospasm occurring during anesthesia INDICATIONS AND USAGE Isoproterenol hydrochloride injection is a beta-adrenergic agonist indicated: • To improve hemodynamic status in patients in distributive shock and shock due to reduced cardiac output. • For treatment of bronchospasm occurring during anesthesia

Source: US FDA prescribing information

How it works

Isoproterenol is a potent nonselective beta-adrenergic agonist with very low affinity for alpha‑adrenergic receptors.

Source: US FDA prescribing information

Dosing overview

DOSAGE AND ADMINISTRATION Initiate Isoproterenol hydrochloride injection at the lowest recommended dose and increase gradually based on patient response. Recommended initial dosage: • Shock: 0.5 mcg to 5 mcg per minute as an intravenous infusion. • Bronchospasm: 10 mcg to 20 mcg intravenous injection

Source: US FDA prescribing information

Contraindications

Isoproterenol hydrochloride injection is contraindicated in patients with: • Tachycardia • Ventricular arrhythmias • Angina pectoris CONTRAINDICATIONS Isoproterenol hydrochloride injection is contraindicated in patients with: • Tachycardia. • Ventricular arrhythmias. • Angina pectoris

Source: US FDA prescribing information

Warnings and precautions

WARNINGS AND PRECAUTIONS • Cardiac arrhythmias and ischemia may be induced by Isoproterenol Hydrochloride Injection. • Sulfite: Isoproterenol Hydrochloride Injection contains metabisulfite, which may cause allergic reaction

Source: US FDA prescribing information

Side effects

The following adverse reactions have been associated with use of isoproterenol. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure. Nervous system disorders: Nervousness, headache, dizziness, visual blurring Cardiovascular: Tachycardia, tachyarrhythmias, palpitations, angina, ventricular arrhythmias, Adams-Stokes attacks, pulmonary edema Respiratory: Dyspnea Other: Flushing of the skin, sweating, mild tremors, pallor, nausea ADVERSE REACTIONS Common adverse reactions with isoproterenol include tachycardia and palpitations

Source: US FDA prescribing information

Interactions

Table 1: Clinically Relevant Interactions with Isoproterenol Epinephrine Clinical Impact Both drugs are direct cardiac stimulants, and their combined effects may induce serious arrhythmias upon simultaneous administration. Intervention Isoproterenol hydrochloride injection and epinephrine should not be administered simultaneously. Drugs that may potentiate clinical response of Isoproterenol Clinical Impact The effects of isoproterenol may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine. Intervention Monitor hemodynamic parameters in patients who concurrently are taking tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium and certain antihistamines. Adjust doses appropriately.

Source: US FDA prescribing information

For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.

All presentations

6 presentations of Isoproterenol, sorted by availability.

MedicineManufacturerRegisterAvailability
Isoproterenol 1 mg/5 mL injectionIntravenousGeneric name—US FDAAvailable on request
Isoproterenol 0.2 mg/1 mL injectionIntravenousGeneric name—US FDAAvailable on request
Isoproterenol 1 mg/5 mL injectionIntracardiac, intramuscular, intravenous, subcutaneousGeneric name—US FDAAvailable on request
Isoproterenol 0.2 mg/1 mL injectionIntracardiac, intramuscular, intravenous, subcutaneousGeneric name—US FDAAvailable on request
Isoproterenol 0.2 mg/1 mL injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request
Isoproterenol 1 mg/5 mL injectionIntramuscular, intravenousGeneric name—US FDAAvailable on request

Regulatory status

Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.

RegisterStatusSource
US FDAFirst approved 19 February 1948Drugs@FDA
EU (EMA)Not recorded—
India (CDSCO)Not yet confirmed against CDSCO approval lists—
United StatesRegisteredUS FDA (NDC directory, openFDA)Checked 12 November 2026

Conditions

Conditions linked to Isoproterenol in public data. This is not a list of approved uses, see the clinical information.

Bronchospasm Congenital heart block

Questions and answers

Is Isoproterenol available for export from India?

Yes, on request. MedsAcross lists 6 presentations of Isoproterenol and sources them for licensed hospitals, importers and physicians against valid import documents.

Is Isoproterenol approved by the US FDA?

Yes. The US FDA first approved Isoproterenol on 19 February 1948, according to Drugs@FDA.

Does Isoproterenol need cold chain shipping?

No listed presentation of Isoproterenol is recorded as needing a cold chain. Storage conditions are shown on each presentation page.

Which ATC class is Isoproterenol in?

Isoproterenol is classified under ATC code C01CA02 (Isoproterenol).

References

  1. Isoproterenol hydrochloride prescribing information (KVK-Tech). U.S. National Library of Medicine, DailyMed. Retrieved 17 March 2026

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