Uses
Pentam 300 (pentamidine isethionate for injection) is indicated for the treatment of pneumonia due to Pneumocystis carinii.
Source: US FDA prescribing information
Molecule
Pentamidine
Also known as pentamidine isethionate
Available on requestOrphan
- Presentations
- 5
- Brands
- 2
- Manufacturers
- 1
- Available from stock
- 0
Pentamidine is an antiprotozoal indicated for the treatment of pneumonia due to Pneumocystis carinii. It is available as inhalant and powder for injection for inhalation, intramuscular and intravenous use. MedsAcross supplies Pentamidine for export from India to licensed hospitals, importers and physicians acting for named patients, with the documents each country requires.
Information from the US FDA prescribing information, retrieved 12 November 2026. Not yet medically reviewed.How we review
Key facts
- Pharmacological class
- Antiprotozoal
- US FDA first approval
- 16 October 1984
- EU status
- Not recorded
- Orphan designation
- Yes
- WHO essential medicine
- Not recorded
- India (CDSCO)
- Not yet confirmed against CDSCO approval lists
- Routes
- Inhalation, Intramuscular, Intravenous
- Dosage forms
- Inhalant, Powder for injection
- Identifiers
- UNII 673LC5J4LQRxCUI 7994CAS 100-33-4DrugBank DB00738Q416206
Clinical information
From the regulator-approved product information. Each section names its source.
Dosing overview
CAUTION: DO NOT USE SODIUM CHLORIDE INJECTION, USP FOR INITIAL RECONSTITUTION BECAUSE PRECIPITATION WILL OCCUR. Pentamidine isethionate should be administered IM or IV only. The recommended regimen for adults and pediatric patients beyond 4 months of age is 4 mg/kg once a day for 14 to 21 days. Therapy for longer than 21 days with pentamidine isethionate has also been used but may be associated with increased toxicity. Intramuscular Injection The contents of one vial (300 mg) should be dissolved in 3 mL of Sterile Water for Injection, USP at 22° - 30°C (72° - 86°F). The calculated daily dose should then be withdrawn and administered by deep IM injection. Intravenous Injection The contents of one vial (300 mg) should first be dissolved in 3 to 5 mL of Sterile Water for Injection, USP, or 5% Dextrose Injection, USP at 22°- 30°C (72° - 86°F).
Source: US FDA prescribing information
Contraindications
Contraindicated in patients with a history of hypersensitivity to pentamidine isethionate.
Source: US FDA prescribing information
Warnings and precautions
Fatalities due to severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported in patients treated with pentamidine isethionate, both by the IM and IV routes. Severe hypotension may result after a single IM or IV dose and is more likely with rapid IV administration. The administration of the drug should, therefore, be limited to the patients in whom Pneumocystis carinii has been demonstrated. Patients should be closely monitored for the development of serious adverse reactions. Extravasations have been reported which, in some instances, proceeded to ulceration, tissue necrosis and/or sloughing at the injection site. While not common, surgical debridement and skin grafting has been necessary in some of these cases, long-term sequelae have been reported. Prevention is the most effective means of limiting the severity of extravasation.
Source: US FDA prescribing information
Side effects
CAUTION: Fatalities due to severe hypotension, hypoglycemia, acute pancreatitis and cardiac arrhythmias have been reported in patients treated with pentamidine isethionate, both by the IM and IV routes. Nephrotoxic events (increased creatinine, impaired renal function, azotemia, and renal failure) are common with the parenteral administration of pentamidine isethionate. The administration of the drug should, therefore, be limited to the patients in whom Pneumocystis carinii has been demonstrated.
Source: US FDA prescribing information
Storage
Store dry product at 20° to 25°C (68° to 77°F). Protect from light.
Source: US FDA prescribing information
For healthcare professionals and buyers. This is not medical advice. Treatment decisions belong to the prescriber.
All presentations
5 presentations of Pentamidine, sorted by availability.
| Medicine | Manufacturer | Register | Availability |
|---|---|---|---|
| Pentamidine 300 mg/300 mg powder for injectionIntramuscular, intravenousGeneric name | — | US FDA | Available on request |
| NebuPent 300 mg/6 mL inhalantInhalation | Fresenius Kabi | US FDA | Available on request |
| Pentam 300 300 mg/3 mL powder for injectionIntramuscular, intravenous | Fresenius Kabi | US FDA | Available on request |
| Pentamidine 300 mg/300 mg inhalantInhalationGeneric name | — | US FDA | Available on request |
| Pentamidine 300 mg/6 mL inhalantInhalationGeneric name | — | US FDA | Available on request |
Brands by market
2 brand names across 1 markets.
United States
Manufacturers
Regulatory status
Approval facts from US FDA, EMA and CDSCO data, and registration status by country where we hold register data.
| Register | Status | Source |
|---|---|---|
| US FDA | First approved 16 October 1984 | Drugs@FDA |
| EU (EMA) | Not recorded | — |
| India (CDSCO) | Not yet confirmed against CDSCO approval lists | — |
| United States | Registered | US FDA (NDC directory, openFDA)Checked 12 November 2026 |
Conditions
Conditions linked to Pentamidine in public data. This is not a list of approved uses, see the clinical information.
Questions and answers
Is Pentamidine available for export from India?
Yes, on request. MedsAcross lists 5 presentations of Pentamidine and sources them for licensed hospitals, importers and physicians against valid import documents.
What brand names does Pentamidine have?
The catalogue lists 2 brand names for Pentamidine, including NebuPent, Pentam 300.
Is Pentamidine approved by the US FDA?
Yes. The US FDA first approved Pentamidine on 16 October 1984, according to Drugs@FDA.
Does Pentamidine need cold chain shipping?
No listed presentation of Pentamidine is recorded as needing a cold chain. Storage conditions are shown on each presentation page.
References
- Pentam 300 prescribing information (Fresenius Kabi). U.S. National Library of Medicine, DailyMed. Retrieved 13 September 2022
Request Pentamidine for export supply
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